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Tramadol - a narcotic analgesic that belongs to the group of analgesics with a mixed mechanism of action, has a strong analgesic activity, provides a quick and lasting effect. The main indications for the use of Tramadol following: moderate and severe pain of various origins (including malignant tumors, acute myocardial infarction, disease, trauma); painful diagnostic or therapeutic procedures. Purpose of tramadol possible during pregnancy (II and III trimester) only under strict medical supervision, if the benefit to the mother outweighs the risk to the fetus. In contrast to morphine, tramadol at therapeutic doses does not depress respiration, does not inhibit the motility of the gastrointestinal tract and does not affect the srdechno-vascular activity. After oral Tramadol is rapidly and almost completely absorbed from the gastrointestinal tract (about 90%). Plasma Cmax is achieved in 2 hours after ingestion. 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